In Vitro Characterization of Aerosolized Albuterol Generated by a Jet Nebulizer and Delivered through a Heated Flow Nasal Cannula System
- Resource Type
- article
- Authors
- Ariel Berlinski; Joshua Spiva
- Source
- Pharmaceuticals, Vol 15, Iss 10, p 1281 (2022)
- Subject
- jet nebulizer
particle size
aerosol MMAD
heated flow cannula
cascade impactor
pediatrics
Medicine
Pharmacy and materia medica
RS1-441
- Language
- English
- ISSN
- 1424-8247
Pediatric patients receiving respiratory support with heated flow nasal cannula (HFNC) systems frequently receive inhaled medications. Most available data have been obtained with vibrating mesh nebulizers that are expensive. Data are lacking regarding the feasibility of using less expensive devices such as continuous output jet nebulizers. The characteristics of the aerosols generated by jet nebulizers operated at different conditions (6 and 9 L/min) were studied alone and connected to a HFNC system and different size cannulas using a cascade impactor and spectrophotometry (276 nm). Aerosol characteristics changed while traveling through the HFNC system. Initial size selection occurred at the exit of the circuit (before connecting to the cannula) with all aerosol