Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
- Resource Type
- article
- Authors
- Annie Y. Yao; Riqiang Yan
- Source
- Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-4 (2020)
- Subject
- Γ-secretase
Presenilin
Nicastrin
Interferon-induced transmembrane protein
IFITM3
Innate immunity
Neurology. Diseases of the nervous system
RC346-429
Geriatrics
RC952-954.6
- Language
- English
- ISSN
- 1750-1326
Abstract The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3.