Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital
- Resource Type
- article
- Authors
- Graziella Hanna Pereira; Doroti O Garcia; Marcelo Mostardeiro; Karina SVN Fanti; Anna S Levin
- Source
- Memorias do Instituto Oswaldo Cruz, Vol 108, Iss 1, Pp 113-115 (2013)
- Subject
- carbapenem-resistant K. pneumoniae
nosocomial outbreak
polymyxin resistance
Microbiology
QR1-502
Infectious and parasitic diseases
RC109-216
- Language
- English
- ISSN
- 1678-8060
0074-0276
This study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of São Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin.