Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress
- Resource Type
- article
- Authors
- Hyeongsun Moon; Jerry Zhu; Leanne R. Donahue; Eunju Choi; Andrew C. White
- Source
- Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
- Subject
- Science
- Language
- English
- ISSN
- 2041-1723
Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.