LPCAT2 controls chemoresistance in colorectal cancer
- Resource Type
- article
- Authors
- Alexia Karen Cotte; Virginie Aires; François Ghiringhelli; Dominique Delmas
- Source
- Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
- Subject
- colorectal cancer
chemoresistance
immunogenic cell death
lipid droplets
lpcat2
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 2372-3556
23723556
Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.