Background: Distribution shifts of the modified Rankin scale (mRs) is used as outcome measure in acute ischemic stroke (AIS) randomized controlled trials (RCT). Distribution across strata of mRs is relevant for sample size calculations and may be affected by eligibility criteria. Aim: We aimed to assess the distribution of mRs scores across its different strata in AIS according to usual eligibility criteria. Methods: We computed follow-up mRs strata distribution between an unselected cohort and samples with (a) time from symptom onset 3 and