The Pulmonary Arterial Hypertension Associated With Ventricular Septal Defects: A Single-Centre Experience In The Republic Of Kazakhstan.
- Resource Type
- article
- Authors
- Aigerim Mullen; Kuat Abzaliyev; Ghazwan Butrous
- Source
- Interdisciplinary Approaches to Medicine, Vol 1, Iss 1, Pp 45-50 (2020)
- Subject
- ventricular septal defect
pulmonary arterial hypertension
children
cardiac surgery
Medicine
- Language
- English
- ISSN
- 2709-2968
2709-2976
The aim of this study was to evaluate the impact of pulmonary arterial hypertension on outcomes following surgical or transcatheter repair of isolated ventricular septal defect in the Republic of Kazakhstan.Echocardiography and catheterisation reports of children with isolated ventricular septal de-fect complicated pulmonary arterial hypertension surgical or transcatheter repair between 2012 and 2016. Amongst 38 children ventricular septal defect mean size was 10.92 ± 6.38mm. The mean systolic pressure in the right ventricle on Echocardiography was 55.42 ± 18.47 mmHg. Mean pulmonary arte-rial pressure by right heart catheterisation was 52.12 ± 29.44 mmHg. The mean end diastolic index for all children was registered as 76.78±19.58ml. Cardiac output was preserved in all children. In the pre-operative period, 9 of these children were treated with sildenafil.One week after the operation, mean right ventricle systolic pressure decreased as for children who did not receive preoperative sildenafil (from 55.5±14.8mmHg to 32.2±14.4mmHg) (p 40% in all children a month after the surgery. In our study prescription of specific drug therapy of pulmonary arterial hypertension with the pur-pose of preparing for surgery has no effect on the effectiveness of surgical treatment of ventricular septal defect. We had had no early postoperative mortality.