The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway
- Resource Type
- article
- Authors
- Ai-Li Li; Yi-qio Sun; Peng Du; Xiang-Chen Meng; Ling Guo; Shuang Li; Chao Zhang
- Source
- Iranian Journal of Allergy, Asthma and Immunology, Vol 16, Iss 2 (2017)
- Subject
- β-lactoglobulin allergy
Peptidoglycan
Regulatory
TLR2/NF-κB signaling
Th17 cells
T-lymphocytes
Medicine
- Language
- English
- ISSN
- 1735-1502
1735-5249
Our previous study reported that Lactobacillus acidophilus(L.acidophilus) key laboratory of dairy science (KLDS) 1.0738 had an effective impact on inhibiting β-lactoglobulin (β-lg) allergy. This study further investigated the anti-allergic activity of peptidoglycan (PGN) isolated from KLDS 1.0738. This study aimed to assess whether toll-like receptor 2 (TLR2)/NF-kappaB (NF-κB) signaling activated by PGN was responsible for reducing allergic inflammation. Our data showed that administration of L. acidophilus PGN inhibited IgE production and improved the Treg/Th17 balance toward a Treg response in a mouse model of β-lg allergy. In addition, treating different doses L. acidophilus PGN to sensitized mice significantly increased TLR2 levels, along with enhancing NF-κB expression, especially in medium and high concentration (p