Objective: To present a step-by-step video of laparoscopic radical nephrectomy and inferior vena cava (IVC) thrombectomy. Patient and surgical procedure: A 55 year-old female diagnosed with a right renal mass with inferior vena cava extension, underwent laparoscopic radical nephrectomy and IVC thrombectomy. Magnetic resonance imaging (MRI) examination revealed an approximately 9 cm mass in the right kidney, combined with a 4 cm mass extending to the right renal vein and IVC. Graded by the thrombus level system, the IVC thrombus of this patient was at level I. The patient was placed in a left decubitus position, and four laparoscopic ports were used. Results: The total duration of the surgery was 2 h and 10 min. The total IVC clamping time was 21 min. Estimated blood loss was 590 mL, and no major intraoperative or postoperative complications occurred. Time to discharge was four days. There was no complication during 12 months of follow-up. Pathological evaluation revealed clear cell renal cell carcinoma with a negative surgical margin. After 12 months of follow-up, there was no recurrence or distant metastasis. Conclusion: We believe that a laparoscopic approach should be offered to selected patients diagnosed with RCC and vena cava tumor thrombus as a minimal invasive option. Optimal patient selection, extensive laparoscopic experience, and multidisciplinary support are crucial for effective surgical treatment.