Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
- Resource Type
- article
- Authors
- Abu Saleh Md Moin; Ahmed Al-Qaissi; Thozhukat Sathyapalan; Stephen L. Atkin; Alexandra E. Butler
- Source
- Frontiers in Endocrinology, Vol 12 (2021)
- Subject
- Neuropilin-1
type 2 diabetes
COVID-19
SARS-CoV-2
ACE inhibitors
ADAM9
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
- Language
- English
- ISSN
- 1664-2392
IntroductionNeuropilin-1(NRP1) is a cofactor that enhances SARS-CoV-2 coronavirus cell infectivity when co-expressed with angiotensin-converting enzyme 2(ACE2). The Renin-Angiotensin System (RAS) is activated in type 2 diabetes (T2D); therefore, the aim of this study was to determine if hypoglycaemia-induced stress in T2D would potentiate serum NRP1(sNRP1) levels, reflecting an increased risk for SARS-CoV-2 infection.MethodsA case-control study of aged-matched T2D (n = 23) and control (n = 23) subjects who underwent a hyperinsulinemic clamp over 1-hour to hypoglycemia(