This study examines how technological entrepreneurship affects national innovativeness based on the Knowledge Spillover Theory of Entrepreneurship. It also examines how technological environments related to intellectual property protection and R&D transfer moderate this relationship. Based on data from 82 countries on technological entrepreneurship, intellectual property protection and innovation activities, this study finds that a higher ratio of technological entrepreneurship in the country enhances national innovativeness. In addition, the level of R&D transfer environment is found to negatively moderate this relationship, and evidence is found for a negative moderating effect of the strength of the intellectual property protection environment in a subsample of innovation-driven economies.