Matrix metalloproteinases and their inhibitors in different acute stroke subtypes
- Resource Type
- research-article
- Authors
- Vukasovic, Ines; Tesija-Kuna, Andrea; Topic, Elizabeta; Supanc, Visnja; Demarin, Vida; Petrovcic, Marija
- Source
- Clinical Chemistry and Laboratory Medicine (CCLM). 44(4):428-434
- Subject
- matrix metalloproteinases
stroke
tissue inhibitor of metalloproteinases
Medical equipment & techniques, Medical diagnosis, Diseases & disorders
Genetics and Molecular Diagnostics
- Language
- English
- ISSN
- 1434-6621
1437-4331
The aim of the study was to determine serum levels of selected matrix metalloproteinases (MMPs) and their natural inhibitors (TIMPs) in the acute phase of different stroke types subdivided according to the Oxfordshire Community Stroke Project (OCSP) classification and the possibility of discriminating stroke types according to their levels. The study included 126 patients with acute stroke within the first 24h of symptom onset, and 124 healthy volunteers. The stroke group had lower MMP-2 concentrations and MMP-2/TIMP-2 ratios (p