As a versatile energy carrier, hydrogen shows enormous promise in a wide range of applications, including energy generation, transportation, and industrial operations. However, because of its unique properties, including flammability and explosiveness, a full awareness of safety standards is required to mitigate the associated hazards. This chapter thoroughly examines safety, prioritizing it across the whole hydrogen lifecycle, from production to application. It investigates the many techniques of hydrogen creation and the significance of handling with caution due to the potential physiological, physical, and chemical hazards. The chapter emphasizes the importance of risk assessment, effective equipment design, training, and regulatory compliance in assuring safety. To encourage safe hydrogen operation, key safety practices such as system design, leak detection, ventilation, fire suppression, and emergency response planning are presented. The chapter also investigates worldwide safety rules, norms, and standards in controlling hydrogen usage, storage, transportation, and construction codes, while recognizing the need for further progress in the hydrogen supply chain. Education and training, including understanding hydrogen properties, regulatory requirements, risk assessment, emergency response, and ongoing professional development, are critical components for improving hydrogen safety. The hydrogen industry can successfully manage risks, safeguard employees and the environment, and encourage the broad use of hydrogen as a clean and sustainable energy alternative by implementing robust safety procedures.