The coronavirus pandemic ushered in new problems and torrents of knowledge to all healthcare workers. In a short time frame, many challenges not previously encountered emerged. When pandemics strike, healthcare workers, especially nurses, are crucial players in the response. They are at the front line working towards prevention as well as cure. Considerable knowledge and experience are required to combat the impact of pandemics, to control and prevent infection, to treat the sick, and to adopt strategies to minimise death, collaborating with the community, with businesses and with families. Excellent knowledge management (KM), knowledge sharing (KS) and experience sharing practices are required. They are the weapons used by health professionals, including nurses, to remain up-to-date and deliver quality health care services during pandemics. Defeating COVID-19 particularly in developing countries has required significant sharing of knowledge and experiences. Have nurses in Africa shared knowledge sufficiently? This chapter outlines an analysis of knowledge sharing about COVID- 19 among nurses in Africa using Actor-Network Theory (ANT). ANT focuses on transformative practices that describe the making of connections, assemblages, or associations. Suggestions for improvements are made.