Objectives We evaluated analytical performance, functionality, reliability, and comparability of cobas® pure integrated solutions (Roche Diagnostics) under routine-like conditions. Methods The study was conducted in Europe and Asia (five sites). Seventy-six applications covering ion selective electrolytes (ISE), clinical chemistry (CC), and immunochemistry (IC) analytes were assessed using Elecsys® immunochemistry assays (Roche Diagnostics). Samples included control material and pseudonymized residual samples (plasma/serum/urine). Analytical performance, functionality, and system reliability were evaluated. An inter-laboratory survey, routine simulation imprecision (RSI) and method comparison experiments, and dedicated workflow runs were conducted. Results Most coefficients of variation (CVs) for repeatability were Conclusions cobas pure integrated solutions demonstrated precise and accurate results under routine-like conditions and comparable results vs. commercial analyzers, supporting implementation into routine practice.