目的 研究CA19-9、s-ULBP2、Dkk1联合诊断胰腺癌的价值及相关性.方法 选择2016年1月至2017年5月住院胰腺癌患者56例,同期健康体检健康者45例和良性胰腺病患者33例作为研究对象,比较3组血清CA19-9、Dkk1与s-ULBP2表达及与临床病理参数的关系.分析CA19-9、s-ULBP2、Dkk1及联合检测诊断胰腺癌的诊断效能.结果 胰腺癌患者血清CA19-9、s-ULBP2及Dkk1含量明显高于良性胰腺病组及健康对照组(P<0.05).CA19-9、s-ULBP2与TNM分期、组织分化程度有关,且CA19-9与肿瘤部位也有关.联合检测诊断值高于任意指标单独检测.结论 CA19-9、s-ULBP2、Dkk1与胰腺癌关系密切,三者联合检测可提高胰腺癌诊断准确率.
Objective To study the value of CA19-9,s-ULBP2 and Dkk1 in the diagnosis of pancreatic cancer and the correlation. Methods From January 2016 to May 2017,56 patients with pancreatic cancer in our hospital were selected,45 healthy subjectsand 33 patients with benign pancreatic diseaseswere enrolled in this study.The differences of serum CA19-9,Dkk1 and s-ULBP2 expression and their relationship with clinicopatholog-ical parameters were compared between the three groups. The diagnostic value of CA19-9,s-ULBP2,Dkk1 and joint detection was analyzed.Results The serum levels of CA19-9,s-ULBP2 and Dkk1 in patients with pancreat-ic cancer were significantly higher than those in the benign pancreatic disease group and the healthy control group (P<0.05).CA19-9 and s-ULBP2 are related to TNM staging and histological differentiation,and CA19-9 is also related to tumor location.Joint test was higher than any of the individual indicators.Conclusion CA19-9,s-ULBP2 and Dkk1 are closely related to pancreatic cancer,and the combined detection of the three can improve the diag-nostic accuracy of pancreatic cancer.