目的:研究卵巢癌患者外周血T淋巴细胞与血清肿瘤标志物的相关性.方法:选取86 例卵巢癌患者为研究对象(恶性组),同期112 例卵巢良性肿瘤患者为对照组(良性组).记录两组患者外周血T淋巴细胞(CD3+、CD4+、CD8+及CD4+/CD8+水平)、血清肿瘤标志物[可溶性间皮素相关肽(SMRP)、人附睾蛋白4(HE4)、糖类抗原125(CA125)]水平,比较不同临床病理特征卵巢癌患者外周血T淋巴细胞、血清肿瘤标志物水平,采用Pearson相关性分析卵巢癌患者外周血T淋巴细胞水平与血清肿瘤标志物水平的相关性.结果:恶性组外周血CD3+、CD4+及CD4+/CD8+水平低于良性组,CD8+及血清SMRP、HE4、CA125 水平高于良性组(P<0.05).临床分期Ⅲ~Ⅳ期、中/低分化、有淋巴结转移卵巢癌患者的外周血CD3+、CD4+及CD4+/CD8+水平分别低于临床分期Ⅰ~Ⅱ期、高分化和无淋巴结转移患者,外周血CD8+及血清SMRP、HE4、CA125水平分别高于临床分期Ⅰ~Ⅱ期、高分化、无淋巴结转移患者(P<0.05).Pearson相关性分析结果显示,卵巢癌患者外周血CD3+、CD4+、CD4+/CD8+水平与血清SMRP、HE4、CA125 水平负相关,外周血CD8+水平与血清SMRP、HE4、CA125 水平正相关(P<0.05).结论:卵巢癌患者外周血T淋巴细胞、血清肿瘤标志物水平与疾病的发生和发展关系密切,两者存在明显相关性.
Objective:To study the correlation between peripheral blood T lymphocytes and serum tumor markers in patients with ovarian cancer.Methods:86 patients with ovarian cancer were selected as the malignant group,and 112 patients with ovarian be-nign tumor were selected as the benign group during the same period.The levels of peripheral blood T lymphocytes(CD3+,CD4+,CD8+ and CD4+/CD8+),serumtumor markers[soluble mesothelin-related peptide(SMRP),human epididymal protein4(HE4),carbohydrate antigen 125(CA125)]of patients in the two groups were recorded.The levels of peripheral blood T lymphocytes and ser-um tumor markers in ovarian cancer patients with different clinicopathological characteristics were compared,and Pearson correlation was used to analyze the correlation between peripheral blood T lymphocytes and serum tumor markers in ovarian cancer patients.Re-sults:The levels of peripheral blood CD3+,CD4+ and CD4+/CD8+ in the malignant group were lower than those in the benign group,and the levels of peripheral blood CD8+,serum soluble mesothelin-related peptide(SMRP),human epididymal protein 4(HE4)and carbohydrate antigen 125(CA125)in the malignant group were higher than those in the benign group(P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in peripheral blood of ovarian cancer patients with clinical stage Ⅲ~Ⅳ,medium/low differentiation and lymph node metastasis were lower than those of patients with clinical stageⅠ~Ⅱ,high differentiation and no lymph node metasta-sis.The levels of peripheral blood CD8+ and serum SMRP,HE4 and CA125 were higher than those of patients with clinical stageⅠ~Ⅱ,high differentiation and no lymph node metastasis(P<0.05).Pearson correlation analysis showed that,the levels of peripheral blood CD3+,CD4+ and CD4+/CD8+ in ovarian cancer patients were negatively correlated with the levels of serum SMRP,HE4 and CA125,the level of peripheral blood CD8+ were positively correlated with serum SMRP,HE4 and CA125 levels(P<0.05).Conclusion:The levels of peripheral blood T lymphocytes and serum tumor markers in ovarian cancer patients were closely related to the occurrence and development of the disease,and there was a significant correlation between them.