Glucocorticoids and nervous system plasticity
- Resource Type
- Academic Journal
- Authors
- Kathryn M Madalena; Jessica K Lerch
- Source
- 中国神经再生研究(英文版). (1):37-41
- Subject
- glucocorticoids
plasticity
stress
neuropathic pain
- Language
- Chinese
- ISSN
- 1673-5374
Glucocorticoid and glucocorticoid receptor (GC/GR) interactions alter numerous aspects of neuronal function. These consequences (e.g., anti-inlfammatoryvs. pro-inlfammatory) can vary depending on the duration of GC exposure or central nervous system (CNS) injury model. In this review we discuss how GC/GR interactions impact neuronal recovery after a central or peripheral nerve injury and discuss how GC exposure duration can produce divergent CNS neuronal growth responses. Finally we consider how new ifndings on gender speciifc immune cell responses after a nerve injury could intersect with GC/GR interactions to impact pain processing.