目的:分析2016年上海市肝癌发病和死亡的基本情况及其在2002-2016年的变化趋势. 方法:采用上海市疾病预防控制中心建立的人群基础肿瘤登记管理系统和死因登记系统收集的2002-2016年肝癌发病和死亡资料,统计分析肝癌发病和死亡数量、粗率、年龄别率和标化率.用Segi's 1960年世界标准人口构成计算标化率.用Joinpoint软件计算标化发病率和死亡率年度变化百分比,分析趋势变化. 结果:2016年上海市肝癌新发3 842例,男性占69.44%,死亡3275人,男性占69.44%,死亡发病比为0.85,粗发病率为26.53/10万,标化发病率为10.60/10万,粗死亡率为22.62/10万,标化死亡率为8.65/10万.肝癌标化发病率和死亡率男女性别比分别为2.91∶1和2.97∶1.年龄别发病和死亡的数量和率值随着年龄的增长而升高.2002-2016年,肝癌的标化发病率年均下降速度3.69%,标化死亡率年均下降速度3.82%. 结论:上海市肝癌发病率和死亡率显著下降,处于全国低水平,但仍是严重危害健康的主要恶性肿瘤之一,应针对其流行特点及危险因素加大综合防控力度.
Objective:To investigate the liver cancer incidence and mortality in 2016 and their trends during 2002 through 2016 in Shanghai. Methods:Data on new liver cancer diagnoses and deaths during 2002 through 2016 were obtained from the Shanghai Municipal Center for Disease Control and Prevention population-based cancer registry and Vital Statistics System,the numbers,crude rates and age-standardized rates of incidence and mortality of liver cancer were calculated.Segi's 1960 world standard population was used to calculate age-standardized rates.Joinpoint analysis was used to analyze the trend changes and to estimate the annual percent change of incidence and mortality rates. Results:There were 3 842 new liver cancer cases in Shanghai in 201 6,69.44%of which were males,and 3 275 deaths of liver cancer,69.44%of which were males.Mortality to incidence ratio was 0.85.The crude rate of incidence was 26.53/105,and the age-standardized rate was 10.60/105.The crude rate of mortality was 22.62/105,and the age-standardized rate was 8.65/105.The Sex ratios for age-standardized incidence and mortality were 2.91∶1 and 2.97∶1,respectively.The age-specific numbers and rates of incidence and mortality increased with age.Overall,the age-standardized rate of incidence of liver cancer was decreased 3.69%on average per year during 2002 through 2016,and the age-standardized rate of mortality of liver cancer was decreased 3.82%on average per year. Conclusion:The incidence and mortality of liver cancer in Shanghai have been remarkably decreased to a low level countrywide,while liver cancer is still one of the leading malignancies and it brings serious threat to public health,comprehensive prevention and control efforts should be strengthened according to its epidemic characteristics and risk factors.