目的 探讨青少年双相情感障碍抑郁发作患者甲状腺激素水平与外显攻击行为的关系.方法 将 64 例青少年双相情感障碍抑郁发作患者中修订版外显攻击行为量表(MOAS)评分≥5分的 34 例患者纳入攻击组,其他 30 例患者纳入非攻击组,比较两组患者甲状腺激素水平[总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)],并分析攻击组患者血清甲状腺激素水平与MOAS评分的相关性.结果 两组患者血清TT3、TT4、FT3、FT4、TSH水平比较,差异均无统计学意义(P>0.05).攻击组患者血清FT3 水平与MOAS总分及自身攻击分量表评分均呈显著正相关(P<0.05);而血清TT3、TT4、FT4、TSH水平与攻击组患者各MOAS分量表评分之间无显著相关性(P>0.05).结论 伴有攻击行为的青少年双相情感障碍抑郁发作患者的血清FT3 水平越高,其自身攻击行为的风险越大.
Objective To explore the relationship between thyroid hormone levels and overt aggressive behaviors in adolescents with depressive episode of bipolar disorders(DEBD).Methods Among 64 adolescents with the DEBD,34 ones with the Modified Overt Aggression Scales(MOAS)score≥5 were assigned to aggressive and other 30 to non-aggressive group,thyroid hormone levels(total triiodothyronine[TT3],total thyroxine[TT4],free triiodothyronine[FT3],free thyroxine[FT4],and thyroid stimulating hormone[TSH])compared between two groups,and the correlations between thyroid hormone levels and MOAS score analyzed in aggressive group.Results Intergroup difference in serum TT3、TT4、FT3、FT4 and TSH levels weren't statistically significant(P>0.05).The serum FT3 levels were positively related to the total and self-aggression score of the MOAS(P>0.05);there were no significant correlations between serum TT3、TT4、FT4、TSH levels and each subscale score of the MOAS in aggressive group(P>0.05).Conclusion The higher the serum FT3 level in DEBD adolescents with aggressive behaviors,the risk of self-aggression greater.