背景:关节腔注射给药已经在骨关节炎治疗中占有重要地位,新型的药物递送系统的开发给予了更多选择.软骨靶向功能是针对治疗骨关节炎时药物附着或留置在软骨层中形成药库,达到缓释和精准药物递送. 目的:综述关节腔注射治疗骨关节炎中各种软骨靶向生物材料和其特点. 方法:以"骨关节炎,药物载体,软骨靶向,osteoarthritis,drug carrier,drug delivery,cartilage targeting,penetrate"为关键词在万方、中国知网、PubMed数据库进行文献检索,根据纳入与排除标准对文章进行筛选、最终选择67篇文章进行综述. 结果与结论:针对软骨靶向生物材料的研究,主要分为两个方向.一是利用静电作用的相互结合,如携带正电荷的生物材料与软骨中的负电多糖结合,这类方案可操作性强,便于修饰,但受限于静电作用本身的缺点,在晚期骨关节炎中表现不佳;二是针对软骨内各成分的特异性结合,这种结合强而可靠,相关生物材料在晚期骨关节炎中表现优异,是未来软骨靶向治疗的重要方向.
BACKGROUND:Intra-articular injection played an important role in the treatment of osteoarthritis and has more options with the development of novel drug delivery systems.The cartilage targeting function is aimed at the adhesion or retention of drugs in the cartilage layer to form a drug bank to achieve slow release and precise drug delivery. OBJECTIVE:To review various cartilage targeting biomaterials and their characteristics in the treatment of osteoarthritis by articular injection. METHODS:Using the term"osteoarthritis,drug carrier,drug delivery,cartilage targeting,penetrate"as key words,relevant articles were searched in CNKI,WanFang and PubMed databases.According to inclusion and exclusion criteria,67 articles were finally selected for further review. RESULTS AND CONCLUSION:The research on cartilage-targeting biomaterials is mainly divided into two directions.One is the combination of electrostatic interaction,such as the combination of positively charged biomaterials and negatively charged polysaccharides in cartilage.This kind of scheme is operable and easy to modify,but limited by the shortcomings of electrostatic interaction itself,it performs badly in advanced osteoarthritis.Another one is the specific binding of various components in cartilage which is strong and reliable,and related biomaterials have excellent performance in advanced osteoarthritis,which is an important direction for future cartilage-targeted therapy.