双相情感障碍(Bipolar Disorder,BD)是慢性和复发性的疾病,其中针对双相抑郁的治疗手段有限.研究发现对季节性抑郁障碍(Seasonal Affective Disorder,SAD)治疗有效的光照治疗(Light Therapy,LT)也可用于治疗双相抑郁.LT通过改善BD昼夜节律紊乱以及调节单胺类神经递质发挥抗抑郁作用.LT作为双相抑郁药物治疗的辅助手段,相对安全而有效.目前需要研究设置更规范、样本量更大、干预及随访周期更长的随机对照研究为LT治疗双相抑郁提供有力证据.
Bipolar Disorder(BD)is a chronic and recurrent disorder,and the treatment for bipolar depres-sion is limited.Studies have found that light therapy(LT),which is effective in the treatment of seasonal affec-tive disorder(SAD),can also be used to treat bipolar depression.LT exerts an antidepressant effect by improving BD circadian rhythm disorders and regulating monoamine neurotransmitters.LT is relatively safe and effective as an adjunctive therapy for bipolar depression.At present,more standardized RCTs with larger sample sizes and longer intervention and follow-up periods are needed to provide strong evidence for LT treatment of bipolar de-pression.