目的:探讨申捷在早期放射性脑损伤防治中的作用。方法将鼻咽癌患者随机分为两组,对照组采用放疗+肾上腺皮质激素方案;治疗组采用放疗+肾上腺皮质激素+申捷方案。申捷每天100 mg,加入到生理盐水或5%葡萄糖水中静脉滴注。两组均于放疗前及放疗后2个月行颅脑MRI、MRS检查,,并测定NAA/Cr和Cho/Cr值。结果对照组放疗后双颞叶NAA/Cr明显下降(t=2.389,P=0.022),治疗组无明显下降(t=0.065,P=0.949);而对照组Cho/Cr放疗后明显升高(t=2.355,P=0.031),治疗组无明显升高(t=1.371,P=0.178)。结论申捷在脑放射性损伤早期阶段有预防及治疗作用。
Objective To explore the preventive effect of Monosialotetrahexosylganglioside Sodium Injection on the radi -ation encephalopathy in the early stage .Methods 56 cases of nasopharyngeal carcinoma patients were divided into 2 groups:The control group were treated with radiotherapy and Dexamethasone Sodium Phosphate Injection ,the treatment group were teated with radiotherapy plus Dexamethasone Sodium Phosphate Injection and Monosialotetrahexosylganglioside Sodium Injection .The content of NAA,Cho,or Cr in brain tissue were detected by Magnetic resonance spectroscopy before radiotherapy and after 2 months.Results In the control group,NAA/Cr was lower after radiotherapy than before in brain parenchyma (t=2.389,P=0.022),Cho/Cr was higher after radiotherapy than before in brain parenchyma (t=2.355,P=0.031).In the treatment group, there's no significant difference in NAA/Cr(t=0.065,P=0.949) and Cho/Cr (t=1.371,P=0.178)before and after radiother-apy.Conclusion Monosialotetrahexosylganglioside Sodium Injection can prevent the occurrence of radiation encephalapathy in the early stage .