目的 探讨慢性肾病(CKD)患者高同型半胱氨酸(Hcy)血症与CKD分期的关系.方法 选取自2013年6月至2015年12月广西河池市人民医院肾内科收治的CKD患者462例为研究对象.检测患者的血浆Hcy水平,分析各期CKD患者中不同Hcy水平所占百分率.采用Logistic回归分析判断发生高Hcy血症的危险因素.结果 在CKD 1~5期患者中,随着CKD分期的增高,高Hcy血症的发病率逐渐增加.单因素回归分析显示,年龄、高血压、糖尿病和CKD分期为CKD患者发生高Hcy血症的独立危险因素.结论 CKD患者肾功能受损程度与血浆Hcy水平增高程度相一致.常规检测CKD患者的血浆Hcy水平,可预防或延缓CKD患者发生心脑血管事件.
Objective To investigate the relationship between the stages of chronic kidney disease(CKD)and hyperhomocysteinemia in CKD patients.Methods A retrospective study was performed on 462 CKD patients received in The People′s Hospital of Hechi from June 2013 to December 2015.The plasma homocysteine (Hcy) levels were detected,and the percentage of homocysteine levels in each stage of CKD was analyzed.Using Logistic regression analysis to determine the risk of high Hcy levels.Results In CKD stage 1 to 5,as the stage of CKD became higher,the incidence of high Hcy levels increase gradually.The univariate regression analysis showed that age,hypertension,diabetes and CKD stage were the independent risk factors for hyperhomocysteinemia in CKD patients.Conclusion The degree of the impairment of renal function is consist of the level of Hcy in plasma of CKD patients.Routine detection of plasma Hcy levels in CKD patients,can prevent or delay the cardiovascular events in CKD patients.