目的:探讨维生素D治疗新生儿感染性肺炎的效果及其对Toll样受体 2(Toll-like receptor 2,TLR2)的影响.方法:选取 2021 年 1 月—2022 年 12 月厦门医学院附属第二医院收治的 85 例新生儿感染性肺炎患儿.根据电脑编号单双差异随机将其分为试验组(42 例)及参考组(43 例).参考组给予常规抗感染治疗,试验组在参考组基础上给予维生素D.比较两组临床疗效、时间指标,治疗前 1 d及治疗 7 d后炎症因子、免疫功能.结果:试验组治疗总有效率高于参考组,差异有统计学意义(P<0.05).试验组病原学检查转阴时间、临床症状消失时间早于参考组,住院时间短于参考组,差异有统计学意义(P<0.05).治疗 7 d后,试验组TLR2 及白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)水平均低于参考组,差异有统计学意义(P<0.05).治疗 7 d后,两组CD3+、CD4+、红细胞C3b受体花环率(adherence rate of complement 3b-receptor on the surface of red blood cell,RBC-C3bR)均高于治疗前 1 d,试验组高于参考组,两组CD8+、红细胞免疫复合物花环率(immune complex adherence rate of red blood cell,RBC-ICR)均低于治疗前 1 d,试验组低于参考组,差异有统计学意义(P<0.05).结论:维生素D治疗新生儿感染性肺炎的效果较佳,且能减轻炎症反应,改善免疫功能.
Objective:To investigate the effects of Vitamin D in the treatment of neonatal infectious pneumonia and its influence on Toll like receptor 2(TLR2).Method:A total of 85 neonatal infectious pneumonia admitted to the Second Affiliated Hospital of Xiamen Medical College from January 2021 to December 2022 were selected.They were randomly divided into experimental group(42 cases)and reference group(43 cases)according to odd-even difference of computer number.The reference group was given conventional anti-infection treatment,and the experimental group was given Vitamin D based on the reference group.The clinical efficacy,time index,inflammatory factors and immune function 1 d before treatment and after 7 d of treatment of the two groups were compared.Result:The treatment total effective rate of experimental group was higher than that of reference group,and the difference was statistically significant(P<0.05).The time of etiological examination to turn negative,the time of clinical symptoms to disappear in the experimental group were earlier than those in the reference group,hospital stay was shorter than that in reference group,and the differences were statistically significant(P<0.05).After 7 d of treatment,the levels of TLR2,interleukin-6(IL-6)and interleukin-8(IL-8)in experimental groups were lower than those in reference group,and the differences were statistically significant(P<0.05).After 7 d of treatment,CD3+,CD4+ and adherence rate of complement 3b-receptor on the surface of red blood cell(RBC-C3bR)in both groups were higher than 1 d before treatment,and those in experimental group were higher than those in reference group,CD8+ and immune complex adherence rate of red blood cell(RBC-ICR)in both groups were lower than 1 d before treatment,and those in experimental group were lower than those of the reference group,and the differences were statistically significant(P<0.05).Conclusion:Vitamin D is effective in the treatment of neonatal infectious pneumonia,and can reduce inflammation reaction and improve immune function.