在抑郁症的发生发展过程中,神经系统涉及多种复杂调节机制.针刺治疗抑郁症疗效显著,其作用机制与单胺类神经递质及其受体、下丘脑-垂体-肾上腺轴、炎症通路、氧化应激、神经可塑性、褪黑素含量密切相关.本文总结近年来针刺抗抑郁的机制研究进展,为抑郁症的治疗提供新思路.
During the occurrence and development of depression,the nervous system involves a variety of complex regulatory mechanisms.Acupuncture is effective in the treatment of depression,and its mechanism of action is closely related to monoamine neurotransmitter and their receptors,hypothalamic-pituitary-adrenal(HPA)axis,inflammatory pathway,oxidative stress,neural plasticity,and melatonin content.In this paper,we summarize the research progress of acupuncture anti-depression mechanism in recent years,and provide a new idea for the treatment of depression.