重症患者在遭受各种因素打击后往往会造成严重的肌肉流失,而在重症监护病房(ICU)内出现的肌肉流失加重了机体的虚弱状态,其效应甚至可持续影响至后ICU阶段机体及器官功能的康复.重症患者的高病死率常常和患者持续的虚弱状态相关,重症患者的肌肉流失并非完全不可逆转,早期诊断和干预可以减少肌肉流失,进而提升ICU救治成功率,并改善存活患者长期预后,减少致残率.本文将从概述、定义、机制、诊断和治疗干预等方面对ICU肌肉流失综合征的诊疗进展进行综述.
Critically ill patients often suffer from severe muscle wasting after being struck by various factors,and the muscle wasting that occurs in the ICU exacerbates the state of weakness,and its effect may even continue to affect the recovery of body and organ function at the post-ICU stage.The high mortality rate of critically ill patients is often associated with a persistent state of weakness.However,muscle loss in critically ill patients is not completely irreversible.Early diagnosis and intervention can reduce muscle loss,which may improve the ICU rescue rate and the long-term prognosis of surviving patients and reduce the rate of disability.In this article,we will review the advances in diagnosing and treating muscle loss syndrome in the ICU in terms of overview,definition,mechanism,diagnosis,and therapeutic intervention.