目的:研究探讨消痰散结方联合卡培他滨维持化疗对晚期胃癌复发转移的影响.方法:选自晚期胃癌患者 80 例,随机抽取平均分两组,各有 40 例,对照组采取卡培他滨维持化疗,观察组采取消痰散结方联合卡培他滨维持化疗,观察比较两组治疗后 1 年内复发、转移及生存情况,并比较治疗前后血清肿瘤标志物、卡氏功能评分(KPS)、血清基质金属蛋白酶 3(MMP-3)、基质金属蛋白酶 9(MMP-9)、T淋巴细胞亚群的变化,观察化疗期间不良反应发生率.结果:观察组总复发转移率 25.00%,明显低于对照组总复发转移率 55.00%(P<0.05);观察组 1 年生存率 67.50%明显高于对照组 1 年生存率 32.50%(P<0.05).观察组治疗后血清肿瘤标志物、KPS评分、T淋巴细胞亚群均明显改善(P<0.05),MMP-3、MMP-9 有所升高,但升高幅度明显小于对照组(P<0.05),组间比较均有统计学差异(P<0.05).观察组的疾病控制率 80.00%明显优于对照组 50.00%(P<0.05);观察组化疗期间总不良反应率 10.00%明显低于对照组 42.50%(P<0.05).结论:晚期胃癌患者采用消痰散结方联合卡培他滨维持化疗,可有助调节机体免疫力,降低复发转移率,预防或减少治疗期间不良反应,提高生活质量.
Objective:To investigate the effect of Xiaotan Sanjie formula combined with capecitabine mainte-nance chemotherapy on the recurrence and metastasis of advanced gastric cancer.Methods:A total of 80 patients with advanced gastric cancer were randomly divided into two groups,with an average of 40 cases each group.The control group received maintenance chemotherapy with capecitabine,while the observation group received treatment with Xi-aotan Sanjie formula combined with maintenance chemotherapy with capecitabine.The recurrence,metastasis,and survival status of the two groups within one year after treatment were observed and compared,and the serum tumor markers,KPS,before and after treatment were compared the changes in serum matrix metalloproteinase-3(MMP-3),matrix metalloproteinase-9(MMP-9),and T lymphocyte subsets were observed,and the incidence of adverse re-actions during chemotherapy was observed.Results:The total recurrence and metastasis rate of 25.00%in the obser-vation group was significantly lower than that of 55.00%in the control group(P<0.05),and the one-year survival rate of 67.50%in the observation group was significantly higher than that of 32.50%in the control group(P<0.05).After treatment,the serum tumor markers,KPS score,and T lymphocyte subpopulations in the observation group were significantly improved(P<0.05).MMP-3 and MMP-9 increased,but the increase was significantly smaller than that in the control group(P<0.05).There were statistical differences between the groups(P<0.05).The disease control rate of 80.00%in the observation group was significantly higher than that of 50.00%in the con-trol group(P<0.05).The total adverse reaction rate of 10.00%during chemotherapy in the observation group was significantly lower than 42.50%in the control group(P<0.05).Conclusion:The combination of Xiaotan Sanjie for-mula and capecitabine maintenance chemotherapy for advanced gastric cancer patients can help regulate the body's immune system,reduce recurrence and metastasis rates,prevent or reduce adverse reactions during adverse periods,and improve quality of life.