目的:探讨肝硬化能量和蛋白质代谢与供给水平,为临床治疗提供参考依据。方法:收治肝硬化患者75例,根据Child-pugh分级,分为A组、B组、C组及对照D组(20例),用间接能量测定系统测定患者脂肪、碳水化合物氧化利用与静息能量消耗情况,并分析患者能量与蛋白质代谢的特点。结果:肝硬化患者 REE 显著高于对照组;与对照相比,肝硬化患者白蛋白、总蛋白及前白蛋白差异明显;3组间PA、ALB差异明显,P<0.05,差异具有统计学意义。结论:肝硬化患者底物氧化以脂肪氧化为主,蛋白质与碳水化合物氧化率减少,患者肝硬化程度与碳水化合物受抑制程度呈明显的正相关。
Objective:To investigate the energy and protein metabolism and supply level in patients with liver cirrhosis,and to provide reference for clinical treatment.Methods:75 patients with liver cirrhosis were selected,they were divided into the group A, the group B,the group C and 20 patients in the group D according to Child-pugh classification,we used indirect energy measurement system for the determination of fat,carbohydrate oxidation and resting energy consumption in patients,and analyzed the characteristics of energy and protein metabolism in patients.Results:The REE was significantly higher in patients with cirrhosis than that in the control group.The albumin,total protein and prealbumin in patients with liver cirrhosis were significantly different compared with the control group.The ALB and PA were significantly different among the 3 groups,P<0.05 the differences were statistically significant.Conclusion:In patients with liver cirrhosis,the fatty oxidation was the main substrate,the oxidation rate of protein and carbohydrate was decreased,and the degree of liver cirrhosis was significantly positive correlated with the inhibition of carbohydrate.