目的 以非小细胞肺癌(non-small cell lung cancer,NSCLC)患者和微小肺结节患者为研究对象,研究NSCLC的面舌脉特征及其与肿瘤标志物的相关性,探索面舌脉数据在NSCLC鉴别诊断中的作用.方法 临床采集NSCLC患者 377 例,微小肺结节患者 368 例,分析并提取其客观化面象、舌象及脉象数据.采用 Wilcoxon 秩和检验分析两组患者面舌脉数据的差异,采用Spearman相关性分析统计面舌脉与肿瘤标志物的相关性.结果 NSCLC组患者的舌象图像指标Per-all、TC-L、TB-CON、TB-ENT、TB-MEAN、TB-L低于微小肺结节组(P<0.05),TC-a、TC-b、TB-ASM、TB-a及TB-b高于微小肺结节组(P<0.05);NSCLC组患者的面象图像指标F-ASM、F-IDM、F-L低于微小肺结节组(P<0.05),F-CON、F-ENT、F-a、F-b高于微小肺结节组(P<0.05);NSCLC组患者的脉图参数h4/h1、h5、t小于微小肺结节组(P<0.05);h3/h1、h1/t1、t1/t、t4/t5、w1/t、w2/t、h1、h3、h4、t4 大于微小肺结节组(P<0.05).纳入研究的血清肿瘤标志物均与面舌脉存在相关性.结论 NSCLC患者和微小肺结节患者的面舌脉特征具有显著差异,面舌脉参数与多种肿瘤标志物之间存在相关性,在临床中可以使用面舌脉数据来辅助良恶性肺结节的诊断.
Objective Taking patients with non-small cell lung cancer(NSCLC)and patients with tiny pulmonary nodules as research subjects,we studied the facial,tongue,and pulse characteristics of NSCLC and their correlation with tumor markers.Then explore the role of facial,tongue,and pulse data in the diagnosis of NSCLC.Methods We collected 377 patients with NSCLC and 368 patients with tiny pulmonary nodules,then analyzed and extracted their facial,tongue,and pulse data.We used Wilcoxon rank-sum test to analyze the difference in facial,tongue,and pulse data between the two groups.We used the Spearman's rank correlation coefficient to represent the correlation between facial,tongue,pulse data and tumor markers.Results The tongue image parameters Per-all,TC-L,TB-CON,TB-ENT,TB-MEAN,and TB-L in the NSCLC group were lower than those in the tiny pulmonary nodules(P<0.05),while TC-a,TC-b,TB-ASM,TB-a,and TB-b were higher than those in the tiny pulmonary nodules group(P<0.05).The facial tongue image parameters F-ASM,F-IDM,and F-L in the NSCLC group were lower than those in the tiny pulmonary nodules group(P<0.05),while F-CON,F-ENT,F-a,and F-b were higher than those in the tiny pulmonary nodules group(P<0.05).The pulsogram parameters h4/h1,h5 and t in the NSCLC group were smaller than those in the tiny pulmonary nodules group(P<0.05);h3/h1,h1/t1,t1/t,t4/t5,w1/t,w2/t,h1,h3,h4,t4 were higher than those in the tiny pulmonary nodules group(P<0.05).All the serum tumor markers included in the study were correlated with facial,tongue,and pulse data.Conclusion There were significant differences in facial,tongue and pulse characteristics between NSCLC patients and patients with tiny pulmonary nodules.And there was a correlation between facial,tongue,pulse parameters and various tumor markers.So we can use facial,tongue,pulse data to assist in the diagnosis of benign and malignant pulmonary nodules in clinical practice.