目的:了解大理市第一人民医院(以下简称"我院")住院患者前列地尔注射剂超说明书用药情况并进行安全分级,为临床合理用药提供依据.方法:随机选择2014—2016年我院住院医嘱1476份,按照药品说明书判断其超说明书用药情况.对各科室、各类疾病用药情况进行统计,并进行安全分级分析,其用药合理性.结果:我院超说明书用药共涉及超适应证用药、超给药途径用药、给药频次不适宜及溶剂不适宜4类.其中超适应证用药共涉及11个科室,骨科、内分泌科、中西医结合科排序居前3位;主要应用于2型糖尿病并发症,拇指、肌腱离断、手掌断伤,腰椎间盘突出或退变、严重骨折、肾病、尿道结石术后等情况.典型病例的超说明书用药分级以B、C级居多.结论:我院前列地尔注射液超说明书用药较为常见,部分存在用药指证,但也有不合理用药情况,临床需引起高度重视.
OBJECTIVE:To investigate the off-label drug use situation of alprostsadil injections in inpatients from the First People ' s Hospital of Dali ( hereinafter referred to as "our hospital") and security classification was conducted , so as to provide reference for the rational drug use in clinic .METHODS:1476 inpatient medical orders during 2014-2016 were randomly selected , the off-label drug use were judged in accordance with the instructions . Statistical analysis was conducted on drug use in various departments and diseases , and security classification and rationality of drug use were analyzed .RESULTS:There were four kinds of off-label drug use in our hospital , including over indications , improper route of administration and cirrational administration times and improper solvent , etc.And a total of 11 departments were involved in over indications , including the most used for orthopaedic department , endocrinology and Chinese and western medicine and urinary surgery , mainly in treatment of type 2 diabetes complications, tendon from broken, hand thumb injury, lumbar disease, kidney disease, cardiovascular disease and severe fracture , etc.CONCLUSIONS:The off-label drug use of alprostsadil injections in our hospital is common , and some has medical evidence; yet there are still some irrational phenomenon , which needs the close attention by the clinic.