目的:分析医院2011年至2014年住院患者抗菌药物使用强度及抗菌药物用药频度(DDDs)与近4年医院病原菌分布关系,为临床合理使用抗菌药物和其他类别药物提供参考。方法回顾性分析医院2011年至2014年的抗菌药物使用情况,以限定日剂量(DDD)为单位,以每100人每天消耗的抗菌药物 DDDs 计算抗菌药物使用强度,对医院近4年细菌病原菌分布进行统计分析。结果医院2011年至2014年全院住院患者抗菌药物平均用药强度分别为64.26,41.73,39.00,33.93,抗菌药物使用强度呈下降趋势。青霉素类﹢酶抑制剂、第1,2代头孢、其他β-内酰胺类与阿莫西林舒巴坦、头孢哌酮舒巴坦钠、头孢硫眯、头孢他啶位于各类别及各品种抗菌药物用药强度的前3位。科室中,呼吸科、重症监护室(ICU)、儿科菌药物使用强度排名靠前,院内细菌中分离量较大的分别是大肠埃希菌、肺炎克雷伯菌和金黄色葡萄球菌,该院排名前3的抗菌药物品种选用基本合理。结论医院专项整治活动的开展对抗菌药物的使用起到了较好的效果,各科室抗菌药物的合理使用有了进一步的加强,继续以抗菌药物专项整治活动为契机,全面促进医院的合理用药水平。
Objective To analyze the relationship of the inpatients Antibiotics Use Density (AUD), antibacterial drugs DDDs and pathogenic bacteria distribution from 2011 - 2014 in the hospital, and to provide reference for clinical rational use of antibiotics and other drugs. Methods By using retrospective method, the use of antibiotics in hospital was analyzed from 2011 - 2014 using defined daily dose (DDD) as a unit, calculated by the AUD DDDS from 100 peoples every day, then analyzed and counted the distribution of pathogenic bacteria from hospital in recent 4 years. Results The average AUD of hospital inpatients from 2011 to 2014 were 64. 26, 41. 73, 39. 00, 33. 93, antimicrobial use showed a downward trend. The top 3 categories and varieties of drugs were Penicillin ﹢ enzyme inhibitor, the 1st or 2nd generation cephalosporin, other beta amides and amoxicillin sulbactam, cefoperazone sulbactam, ceftazidime, cephathiamidine. The top rank use of antibiotics were respiratory, ICU (intensive care unit) and pediatric. The large amount of separation were Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus in hospital. The top 3 of the selection of antimicrobial agents were basically reasonable. Conclusion After the special rectification, the use of antibiotics in hospital is better than before. The rational use of the antimicrobial agents in different departments has been further strengthened, and can be an opportunity for special rectification activities of antimicrobial drugs, strengthen the management of the use of other drugs, as well as comprehensively promoting the rational drug use in the hospital.