目的 应用Meta分析方式对中医药在男性更年期综合征治疗中的效果进行综合评价.方法 计算机检索PubMed、Cochrane library、Web of Science、CBM、CNKI、维普、万方等数据库,同时手工检索相关文献,筛选自建库-2023年4月使用中医药治疗男性更年期综合征的随机对照试验(RCT),由2名研究员严格按照制定的纳排标准筛选、分析文献.使用Cochrane偏倚风险评估工具对符合要求的试验进行质量评价后提取数据.使用RevMan5.4软件进行分析.结果 共纳入合格文献16篇,患者共1 220人.Meta分析结果显示,治疗组可以改善患者体能/心血管评分(MD=-0.87,95%CI[-1.55,-0.20],P=0.01)和精神心理评分(MD=-0.47,95%CI[-0.88,-0.05],P=0.03),疗效优于对照组.但在性功能评分、睾酮(testosterone,T)、性激素结合球蛋白(sexHormone-binding globulin,SHBG)、黄体生成素(luteinizing hormone,LH)、卵泡刺激素(follicle stimulating hormone,FSH)、雌二醇(estradiol,E2)及临床疗效方面,与对照组之间均无统计学意义.结论 中医药治疗男性更年期综合征表现出与睾酮替代疗法相当的整体疗效,并在体能/心血管、精神心理评分方面较睾酮替代疗法有一定的优势.
Objective To comprehensively assess the effect of traditional Chinese medicine in the treatment of male climacteric syndrome by means of meta-analysis.Methods PubMed,cochrane Library,web of Science,CBM,CNKI,VIP,wanfang and other databases were searched by computer,and relevant literatures were retrieved manually.A randomized controlled trial(RCTS)on the treatment of male menopause syndrome with traditional Chinese medicine was screened from the self-built database until April 2023,and literatures were screened and analyzed by 2 researchers strictly in accordance with the established criteria.Data were extracted from eligible trials after quality assessment using the cochrane bias risk assessment tool.RevMan5.4 software was used for analysis.Results A total of 16 qualified literatures were included,including 1 220 patients.Meta-analysis resultsshowed that the physical fitness/cardiovascular score(MD=-0.87,95%CI[-1.55,-0.20],P=0.01)and psychologic score(MD=-0.47,95%CI[-0.88,-0.05],P=0.03)were improved in the experimental group,and the efficacy was better than that in the control group.However,sexual function score,serum T,SHGB,LH,FSH,E2 and there was no statistical significance in clinical efficacy compared with the control group.Conclusion The overall efficacy of traditional Chinese medicine in the treatment of male climacteric syndrome is similar to that of testosterone replacement therapy,and superior to that of testosterone replacement therapy in physical fitness/cardiovascular and psychopsychological scores.