目的 分析慢性牙周炎患者血清中转化生长因子β1(TGF-β1)、肿瘤坏死因子α(TNF-α)和牙龈组织中血管内皮生长因子(VEGF)的表达变化.方法 选取 2017 年 1 月-2021 年 12 月于昌邑市人民医院就诊的慢性牙周炎患者 40 例作为试验组,并选取 40 例同期牙周健康者作为对照组.比较两组血清TGF-β1、TNF-α及牙龈组织VEGF表达,并研究TGF-β1、TNF-α、VEGF与临床特征的关系,另采用Pearson相关性分析TGF-β1 与TNF-α、VEGF的关系.结果 试验组血清TGF-β1 表达低于对照组,血清TNF-α及牙龈组织中VEGF表达高于对照组(P<0.05);慢性牙周炎患者血清TGF-β1、TNF-α、VEGF表达与牙周炎严重程度有关(P<0.05),但与牙周炎持续时间、牙齿缺损数目无关(P>0.05);Pearson相关性分析显示,慢性牙周炎患者血清TGF-β1 低表达水平与TNF-α(r=-0.301,P=0.029)及组织VEGF(r=-0.281,P=0.039)的高表达呈负相关.结论 慢性牙周炎患者血清中TGF-β1 表达降低,而血清TNF-α及组织VEGF表达升高,TGF-β1 表达与TNF-α、VEGF表达密切相关,三者在慢性牙周炎的形成中起一定作用.
Objective To analyze the expression changes of transforming growth facatou-β1(TGF-β1),tumor necrosis factor α(TNF-α)in serum and vascular endothelial factor(VEGF)in gingival tissue in patients with chronic periodontitis.Methods Forty patients with chronic periodontitis who were treated in Changyi People's Hospital from January 2017 to December 2021 were selected as the experimental group,and 40 periodontally healthy people in the same period were selected as the control group.Serum TGF-β1,TNF-α and VEGF expression in gingival tissue were compared between the two groups,and the relationship between TGF-β1,TNF-α,VEGF and clinical characteristics was studied.Pearson correlation was used to analyze the relationship between TGF-β1 and TNF-α,VEGF.Results The expression of serum TGF-β1 in the experimental group was lower than that in the control group,and the expression of serum TNF-α and VEGF in gingival tissue was higher than that in the control group(P<0.05).The expression of serum TGF-β1,TNF-α and VEGF in patients with chronic periodontitis was related to the degree of periodontitis(P<0.05),but not related to the duration of periodontitis and the number of tooth defects(P>0.05).Pearson correlation analysis showed that the low expression level of serum TGF-β1 in patients with chronic periodontitis was negatively correlated with the high expression of TNF-α(r=-0.301,P=0.029)and tissue VEGF(r=-0.281,P=0.039).Conclusion The expression of serum TGF-β1 of patients with chronic periodontitis is decreased,while the expression of serum TNF-αand VEGF in gingival tissue is increased.The expression of TGF-β1 is closely related to the expression of TNF-α and VEGF,which play a certain role in the formation of chronic periodontitis.