目的 评价肝肿瘤动态三维超声造影(3D-CEUS)与二维超声造影(2D-CEUS)定量分析时间-强度曲线(TIC)参数的相关性与一致性.方法 对30例肝肿瘤患者行常规超声、 2D-CEUS和动态3D-CEUS检查,采用定量分析软件对原始动态数据进行定量分析,均取整个病灶为感兴趣区,分别生成TIC曲线并拟合,采用拟合度(QOF)来评价拟合曲线和初始曲线的符合程度.比较同一个病灶生成的相应2D-CEUS与3D-CEUS定量分析参数:峰值强度(PI)、斜率(S)、曲线下面积(AUC)、达峰时间(TTP)及平均渡越时间(MTT)的一致性和相关性.结果 2D-CEUS和3D-CEUS时间定量参数(MTT和TTP)的一致性好,一致性分别为0.97和0.96,相关系数分别为0.94和0.93.S、PI及AUC的相关性较好,相关系数分别为0.92 、 0.72和0.65 .结论 3D-CEUS定量分析参数与2D-CEUS有较高的一致性,稳定可靠,可用于临床评估肝肿瘤的血流灌注情况.
Objective To evaluate the correlation and consistency of dynamic three-dimensional contrast-enhanced ultrasonography ( 3D-CEUS ) and two-dimensional contrast-enhanced ultrasonography (2D-CEUS) in the time-intensity curve ( TIC) parameters of quantitative analysis in liver neoplasms. Methods Thirty patients were examined with 2D-CEUS and dynamic 3D-CEUS.The dynamic raw data were analyzed by quantitative analysis software. The regions of interest were manually selected around the entire lesion;TIC curves were generated and fitted respectively. Quality of fit ( QOF) was used to evaluate the degree of fit between the fitted curve and the initial ccoefficients of S,PI and AUC were 0.92,0.72 and urve. The corresponding 2D-CEUS and 3D-CEUS quantitative parameters of the same lesion were compared,including peak intensity ( PI),slope ( S),area under curve (AUC),time to peak (TTP) and mean transit time (MTT). The correlation of the intensity-related quantitative parameters and the consistency of the time-related quantitative parameters were analyzed between the two kinds of CEUS. Results The consistency of time related quantitative parameters,including MTT and TTP,were 0.97 and 0.96,and the correlation were 0.94 and 0.93. The correlation 0.65,respectively. Conclusions The quantitative results of 3D-CEUS are stable and reliable,and have fair concordance with 2D-CEUS. Dynamic 3D-CEUS can be used for clinical evaluation of the blood perfusion of liver neoplasms.