酞嗪酮类化合物是一类具有良好药理活性的含氮杂环化合物.以邻甲酰基苯甲酸、苯肼为原料,以乙醇作为溶剂,在纳米CuO的催化下回流8 h,以较高的收率合成了2-芳基取代酞嗪酮类化合物10个,并通过1 H-NMR、13C-NMR、MS、熔点等手段对产物进行了表征.结果表明,该合成酞嗪酮类化合物的方法具有操作简便、收率较高、溶剂与催化剂廉价易得等优点,且催化剂可重复使用.
Phthalazinones is one of the nitrogen control heterocycle compounds and proved to have extensive pharmacological activities.Ten of substituted phthalazine-1 (2H )-ones were prepared in good yields with 2-carboxybenzaitehyde and aromatic hydrazines as the sub-strate,alcohol as the solvent and nano CuO as the catalyst.All of the products were charac-terized by 1 H-NMR,13C-NMR,MS and melting points test.This method has many advanta-ges,such as simple experimental procedures,environmentally friendly solvent,inexpensive and recyclable catalyst.