雷公藤红素是从中药雷公藤的根皮中分离得到的有效成分之一,具有抗肿瘤、抗病毒、免疫抑制等活性.最近研究发现,其可通过改善胰岛素抵抗,增加瘦素受体敏感性和能量消耗,抑制脂肪细胞分化,抗炎和抗氧化等机制减轻体重和改善糖、脂代谢,表明雷公藤红素在治疗代谢综合征及相关异常中具有潜在作用.
Celastrol,one of the most promising medicinal ingredient extracted from the root of Tripterygiumwilfordii Hook,possesses anti-tumor,anti-virus and immunosuppressive effect.Recent researches showed its effects on reducing body weight,alleviating glucose and lipid,the possible mechanisms included reversing insulin resistance,increasing leptin sensitivity and energy expenditure,inhibiting adipocyte differentiation,anti-inflammatory,anti-oxidant and so on.It indicates celastrol plays potential roles in the treatment of metabolic syndrome and related dysfunction.