目的 探讨胸水中γ-干扰素特异性效应T细胞检测(T-SPOT.TB)对结核性胸膜炎的诊断价值.方法 实验组:结核性胸膜炎患者35例,对照组:非结核性胸膜炎患者40例,分别检测其外周血及胸水特异性效应T细胞释放的γ干扰素,通过绘制受试者工作特征曲线(ROC曲线),比较其特异度、敏感度.结果 胸水T-SPOT.TB试验对于结核性胸膜炎的诊断效果明显高于外周血,特异性,敏感性达90%以上.其ROC曲线下面积大于90%.结论 胸水γ-干扰素特异性效应T细胞检测对于结核性胸膜炎的诊断有着较高的敏感性和特异性,有助于结核性胸膜炎的早期诊断和鉴别诊断.
Objective To evaluate the diagnostic value of pleural fluid T-SPOT counts for patients with tuberculous pleurisy.Methods There were 35 patients with tuberculous pleurisy(the TB group) and 40 patients with non-tuberculous pleurisy (the non-TB group).Peripheral blood,pleural fluid T-SPOT counts and pleural effusion ADA level were measured.Their sensitivity and specificity for diagnosing were determined by ROC curve.Results The pleural fluid TSPOT counts were significantly higher than the paired counts from peripheral blood and the relative pleural effusion ADA levels.The specificity and sensitivity of pleural fluid T-SPOT counts can be over 90%.The area under the ROC curve is greater than 90 %,too.Conclusion The pleural fluid T-SPOT counts had higher sensitivity and specificity for the diagnosis of tuberculous pleurisy and this test may have an important value for early diagnosis of tuberculous pleurisy.