非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)被认为是代谢综合征(metabolic syndrome,MetS)的肝脏表现,2020 年正式更名为代谢性脂肪肝(metabolic dysfunction-associated fatty liver disease,MAFLD),其全球患病率约为 25%.结直肠癌(colorectal cancer,CRC)多由结直肠腺瘤发展而来,是全球第三大常见癌症和第二大癌症死亡原因.近年来,虽然已有研究提出NAFLD与结直肠肿瘤(colorectal neoplasia,CRN)有关,但 NAFLD 与 MAFLD 并不完全等同,MAFLD 对 CRN 的作用还有待研究,因此本文就 NAFLD与 CRN关系的最新研究进展作一综述,并讨论新定义 MAFLD对与 CRN相关性研究的影响.
Nonalcoholic fatty liver disease(NAFLD)was considered a liver manifestation of metabolic syndrome(MetS).In 2020,NAFLD was redefined as metabolic dysfunction-associated fatty liver disease(MAFLD),with an es-timated prevalence of 25%globally.Colorectal cancer(CRC)which ranked third in terms of incidence and second in terms of mortality was mainly developed from colorectal adenoma.Recently,although NAFLD has been found to be asso-ciated with colorectal neoplasia(CRN),NAFLD and MAFLD are not identical.The role of MAFLD in CRN remained unclear.Therefore,we reviewed the latest findings in the relationship between NAFLD and CRN,and discussed the im-pact of the new definition of MAFLD on CRN.