目的:探讨以阴性症状为主的男性慢性精神分裂症患者血清白细胞介素 (IL) -6、IL-10及叶酸水平及其与神经认知功能的相关性.方法:采用阴性症状评定量表 (SANS) 、连线测验 (TMT) 、定步调连续加法任务测验 (PASAT) 、Stroop测验评估60例以阴性症状为主的男性慢性精神分裂症患者 (患者组) 病情及认知功能;使用酶联免疫吸附法 (ELISA) 检测其血清IL-6、IL-10和叶酸水平;结果与55名健康对照者 (对照组) 比较;分析患者血清IL-6、IL-10及叶酸水平与认知功能及病情的关系.结果:与对照组比较, 患者组TMT、PASAT、Stroop成绩显著低下 (P均<0. 01) ;血清IL-6水平显著升高 (P <0. 05) , IL-10及叶酸水平显著降低 (P均<0. 01) ;患者组血清IL-6水平与TMT-B时间呈正相关 (P <0. 05) , IL-10水平与Stroop测验、PASAT评分呈正相关, 与TMT时间及SANS总分呈负相关 (P <0. 05或P <0. 01) ;血清叶酸水平与认知功能测验结果及SANS总分不相关.结论:以阴性症状为主的男性慢性精神分裂症患者存在免疫功能异常、叶酸降低和广泛认知功能障碍;血清IL-10水平可能是其潜在的生物学标记物之一.
Objective: To study the levels of serum interleukin (IL) -6, IL-10, folic acid and neurocognitive function in male chronic schizophrenic patients with mainly negative symptoms, and the correlations among them. Method: The condition and neurocognitive function of 60 male chronic schizophrenic patients with mainly negative symptoms (case group) were assessed by scale for assessment of negative symptoms (SANS) , trail making test (TMT) , paced auditory serial addition task (PASAT) ; and their serum IL-6, IL-10 and folic acid levels in all subjects were detected by enzyme linked immunosorbent assay (ELISA) . The results were compared with 55 normal controls (control group) . Results: Compared to the control group, the results of neurocognitive test (TMT, PASAT, Stroop) in the case group were significantly lower (all P < 0. 001) ; the serum IL-6 level was remarkabely increased (P < 0. 05) and IL-10 and folic acid levels were remarkabely decreased (all P < 0. 001) . In the case group, the serum IL-6 level was positively correlated with time of TMT-B (P < 0. 05) , IL-10 level was positively correlated with scores of Stroop test and PASAT (P < 0. 05 or P <0. 01) , and negatively correlated with times of TMT and total score of SANS (P < 0. 05 or P < 0. 01) . The serum folic acid level was not correlated with all the results of cognitive tests and total scores of SANS.Conclusion: The male chronic schizophrenic patients with mainly negative symptoms have immune dysfunction, lower serum folic acid level and extensive cognitive impairment. Serum IL-10 may be a potential biological marker for negative symptoms.