藤黄酸作为中药藤黄的主要生物活性成分,通过多种机制发挥抗肿瘤作用,包括诱导细胞凋亡、抑制肿瘤血管的生成和转移以及逆转肿瘤的多药耐药等;尤其是在乳腺癌治疗中可发挥多种抗肿瘤作用,有望成为乳腺癌的治疗药物.但藤黄酸自身存在缺陷,如水溶性差、半衰期短等,限制其临床应用.随着纳米载药制剂的不断发展,有望改善藤黄酸的不足,发挥藤黄酸强大的抗肿瘤作用.因此,综述近五年藤黄酸治疗乳腺癌的相关文献,以期为最大化藤黄酸抗乳腺癌奠定基础.
Gambogic acid,as the main bioactive component of gambogic,exerts anti-tumor effects through various mechanisms,in-cluding induction of apoptosis,inhibition of tumor angiogenesis and metastasis,and reversal of tumor multidrug resistance.In particu-lar,it can exert a variety of anti-tumour effects in the treatment of breast cancer and is expected to become a breast cancer treatment drug.However,gambogic has its own defects,such as poor water solubility and short half-life,which limit its clinical application.With the continuous development of nano-loaded drug formulations,it is expected to improve the shortcomings of gambogic acid and bring in-to play its powerful anti-tumour effects.Therefore,we reviewed the literature related to gambogic acid in breast cancer treatment in the past five years,in order to lay the foundation for maximizing gambogic acid against breast cancer.