本文报道1例急性淋巴细胞白血病患儿在造血干细胞移植围手术期使用艾沙康唑治疗肺毛霉病的案例.临床药师参与会诊,根据患儿病情选择艾沙康唑治疗,并确定儿童用药剂量.治疗期间监测安全性和有效性,治疗后患儿肺内病变改善.艾沙康唑作为新药,儿童使用经验有限,临床药师查阅文献,制订用药方案,实施药学监护,保障儿童用药合理与安全.
This paper reports a case of clinical practice of using isavuconazole to treat pulmonary mucormycosis in a child with acute lymphocytic leukemia during the perioperative period of hematopoietic stem cell transplantation.Clinical pharmacists participated in consultations and suggested the use of isavuconazole to treat pulmonary mucormycosis based on the patient's condition,determined the medication dosage for children,and monitored safety and effectiveness during treatment.After treatment,the pulmonary lesions in the child improved.As a new drug,there was limited experience of isavuconazole in children's use.Clinical pharmacists have consulted literature,formulated medication plans,and implemented pharmaceutical monitoring to ensure the rational and safe use of medication in children.