目的:探讨盐酸氮卓斯汀喷剂联合地氯雷他定对变应性鼻炎患者炎症因子、细胞功能和IgE水平的影响。方法选取2014年6月~2015年12月温州医科大学附属第一医院收治的变应性鼻炎患者92例,按照随机数字表法分为试验组( n=46)和对照组(n=46),对照组给予地氯雷他定片口服治疗,1片/次,1次/天,试验组在对照组基础上加用盐酸氮卓斯汀喷剂喷鼻治疗,每鼻孔1喷,早晚各1次。4 w后观察2组患者的临床疗效,ELISA检测血清IFN-γ、IL-4、IL-8及IgE水平,IFN-γ/IL-4为Thl/Th2的值,流式细胞仪测定T细胞亚群CD4+、CD8+水平。结果治疗4 w后2组患者的鼻塞、鼻痒、流涕、喷嚏及鼻腔内改变积分均降低,且试验组患者低于对照组,差异有统计学意义(P<0.05)。试验组患者的总有效率93.48%高于对照组78.26%,差异有统计学意义(χ2=4.389, P=0.036)。治疗后2组患者的血清IFN-γ高于治疗前,而IL-4、IL-8炎症因子水平低于治疗前,试验组明显优于对照组,差异有统计学意义( P<0.05)。2组患者的T细胞CD4+、CD8+及Thl/Th2值均高于治疗前,且试验组高于对照组,差异均有统计学意义( P<0.05)。2组患者的血清IgE水平均低于治疗前,且试验组低于对照组,差异有统计学意义( P<0.05)。结论盐酸氮卓斯汀喷剂联合地氯雷他定可提高变应性鼻炎的临床疗效,降低炎症反应,增强机体免疫功能,改善血清IgE水平。
Objective To explore the effect of azelastine hydrochloride nasal spray combined with desloratadine to inflammatory factors, cell function and IgE of patients with allergic rhinitis.Methods 92 cases of allergic rhinitis patients treated in the first affiliated hospital of wenzhou medical college hospital from June 2014 to December 2015 were divided into experimental group(n=46) and control group(n=46) according to the random number table method.The control group was given oral loratadine tablets, one piece per time, one time per day, while the experimental group was given azelastine hydrochloride nasal spray on the basis of the control group,each nostril one spray, one time in the morning and night.The clinical efficacy of two groups of patients would be observed after 4 weeks,ELISA would be used to detect serum levels of IFN-γ, IL-4, IL-8 and IgE level, and IFN-γ/IL-4 was the value of Thl/Th2,flow cytometry instrument was used to the determination of T cell subgroup CD4 +,CD8 + cells.Results 4 weeks after treatment,stuffy nose, nasal itching, runny nose, sneezing and nasal cavity change points are lower than before the treatment in both the two groups.Experimental group obviously lower than the control group, the difference was statistically significant ( P <0.05 ).The total effective rate of treatment group is higher than the control group,the difference was statistically significant(χ2 =4.389,P=0.036).The serum level of IFN-γis higher than before treatment in both the two groups.IL-4, IL-8 inflammatory factor levels were lower than before treatment,the experimental group was better than control group,the difference was statistically significant(P<0.05).CD4 +,CD8 +of T cells and Thl/Th2 values are higher than before the treatment in both the two groups,the experimental group was higher than control group, the difference was statistically significant ( P<0.05 ).Serum IgE levels were lower than before the treatment in both the two groups,the experimental group was lower than control group,the difference was statistically significant (P<0.05).Conclusion The therapy of azelastine hydrochloride nasal spray combined with desloratadine can improve the clinical effect of the treatment of allergic rhinitis,reduce inflammation,strengthen the body's immune function, improve thelevel of serum IgE.