目的:探讨HbA1 c与MS及其组分的关系。方法采用多阶段分层随机整群抽样方法抽取江苏省常州市武进区年龄≥18岁常住居民600名进行问卷调查、体格检查和实验室检测。结果研究对象平均 HbA1c(5.79±1.01)%。随 HbA1c水平升高,中心性肥胖、血压升高、FPG升高、TG升高、HDL‐C降低和MS者比例呈升高趋势[85(24.15%)vs 85(47.75%)vs 46(65.71%);199(56.53)vs 122(68.54%)vs 60(85.71%);104(29.55%)vs 96(53.93%)vs 69(98.57%);90(25.57%)vs 56(31.46%) v s 41(58.57%);111(31.53%) v s 49(27.53%) v s 38(54.29%);56(15.91%) v s 63(35.39%) v s 45(64.29%) ,P趋势<0.05]。Logistic多元回归分析结果显示,校正性别、年龄、文化程度、职业、吸烟和饮酒等因素的同时,校正FPG升高,HbA1c水平升高仍是MS、中心性肥胖、TG升高的独立危险因素,HbA1c≥6.5%组发生MS、中心性肥胖和 TG升高风险分别为 HbA1c<5.7%组的3.07(OR=3.07,95% CI:1.60~5.89)、3.88(OR=3.88,95% CI:2.00~7.52)和3.26(OR=3.26,95% CI:1.50~5.78)倍。结论 HbA1 c水平与MS及其组分相关,HbA1 c水平可能是MS患病的预测指标。
Objective To investigate the relationships of HbA1 c with MS and its components.Methods A total of 600 rural residents aged≥18 years in Wujin district of Changzhou were enrolled by multi‐stage cluster sampling method. All the participants were investigated by questionnaires ,physical examination and laboratory monitoring. Results The average HbA1 c level was (5.79 ± 1.01)%.Along with HbA1ctertiles change(<5.7% ,5.7% ~6.4% ,≥6.5% ) ,the prevalence of central obesity ,elevated blood pressure ,elevated FPG ,elevated TG ,decreased HDL‐C and MS were increased or decreased respectively as following [85(24.15% ) vs 85(47.75% ) vs 46(65.71% ) ,199(56.53% ) vs 122(68.54% ) v s 60 (85.71% );104 (29.55% ) v s 96 (53.93% ) v s 69 (98.57% );90 (25.57% ) v s 56 (31.46% ) v s 41 (58.57% );111 (31.53% ) vs 49 (27.53% ) vs 38 (54.29% );56 (15.91% ) vs 63 (35.39% ) vs 45 (64.29% )] ,(P< 0.05).Multivariate logistic regression analysis showed that the risk of MS ,central obesity and elevated TG were independently associated with HbA1 c after adjusting for gender ,age , education level ,occupation ,smoking ,drinkingand additionally adjusting for elevated FPG. The risk of MS , central obesity and elevated TG in HbA1c≥6.5% group were 3.07 (OR=3.07 ,95% CI:1.60~5.89) , 3.88 (OR=3.88 ,95% CI:2.00~7.52) and 3.26 (OR= 3.26 ,95% CI:1.50~ 5.78) times compare to HbA1c<5.7% group. Conclusion HbA1c level is associated with MS and its components ,and HbA1c may be a predictor of MS.