目的 研究血友病A型患者疾病的严重程度与焦虑、抑郁情绪的关系,以及对患者生活质量的影响.方法 将33例血友病A型患者按疾病严重程度分为重型组(FⅧ浓度<1%)8例和轻/中型组(FⅧ浓度≥1% ~ 25%)25例,采用广泛性焦虑量表(GAD-7)、抑郁症筛查量表(PHQ-9)评估患者的焦虑和抑郁情绪,采用健康调查问卷(SF-36)评估患者的生活质量,比较不同严重程度患者焦虑抑郁的状态以及对生活质量的影响.结果 重型组GAD-7及PHQ-9量表分值均高于轻/中型组,差异均有统计学意义(均P<0.05);SF-36量表中生理职能的分数两组间差异有统计学意义(P<0.05).结论 重型血友病A型患者的焦虑、抑郁程度显著高于轻/中型患者;重型血友病A型患者与轻/中型血友病A型患者之间生活质量的差异主要体现在生理职能的变化上.
Objective To study the anxiety,depression and quality of life in patients with hemophilia type A.Method Thirty three patients with hemophilia type A aged 18~60 year were enrolled in the study from January to September 2016.The patients were classified as severe (FⅧ level<1%,n=8) and mild/moderate (FⅧ level 1%~25%,n=25) groups.The anxiety ant depression of patients were assessed with Generalized Anxiety Disorder (GAD-7) scale and Patient Health Questionnaire (PHQ-9),the quality of life was assessed with Medical Outcome Study Short from Health Survey (SF-36).According to the integral change statistical analysis,the anxiety and depression status was compared between patients with different degree o severity and its influence to the quality of life was analyzed.Results The GAD-7 and PHQ-9 scores were higher in severe group than those in light/moderate group(P<0.05).Role-physical (RP) of SF-36 scale score was statistically significant differen between the two groups (P<0.05).Conclusion Patients with severe hemophilia type A have higher degree of anxiety and depression than those with mild/moderate disease.The lower quality of life of patients with severe disease mainly reflects on the changes of role-physical.