[目的]观察耳迷走神经电刺激治疗多囊卵巢综合征(PCOS)患者负性情绪的有效性.[方法]采用随机数字表法将60例PCOS患者随机分为电刺激组和对照组,每组30例.两组患者均于月经第 5天接受生活方式干预,电刺激组同时联合使用耳迷走神经电刺激治疗,两组治疗均以 1个月为 1个疗程,共治疗 3个疗程.比较两组患者治疗前后的焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、中医症状评分、体质量指数(BMI)、糖代谢指标[空腹胰岛素(FINS)、空腹血糖(FBG),计算稳态模型胰岛素抵抗指数(HOMA-IR)]及炎症因子[血清白细胞介素(IL)-1、IL-6、肿瘤坏死因子-α(TNF-α)]水平.[结果]与治疗前比较,治疗后电刺激组患者SAS、SDS评分降低,中医症状评分降低,FINS、FBG、HOMA-IR降低,血清IL-1、IL-6 和TNF-α水平降低(P<0.05);对照组中医症状评分降低,FINS、FBG、HOMA-IR降低(P<0.05).与对照组比较,治疗后电刺激组SAS、SDS评分降低,中医症状评分降低,FINS、FBG、HOMA-IR降低,血清IL-1、IL-6 和TNF-α水平降低(P<0.05).[结论]在PCOS患者治疗中应用耳迷走神经电刺激,能够有效改善患者焦虑、抑郁状态,还可以改善患者血糖代谢,减轻炎症反应.
[Objective]To observe the effect of auricular vagus nerve electrical stimulation on negative emotion in patients with polycystic ovary syndrome(PCOS).[Methods]The 60 patients with PCOS were randomly divided into electrical stimulation group and control group,with 30 patients in each group.Both groups received lifestyle intervention on the 5th day of menstruation,and the electrical stimulation group was combined with auricular vagus nerve electrical stimulation.Both groups were treated for 1 month as a course of treatment,with a total of 3 treatments.The scores of self-rating Anxiety Scale(SAS)and self-rating Depression Scale(SDS),as well as traditional Chinese medicine(TCM)medicine symptom score,body mass index(BMI),glucose metabolism index(FINS)and fasting blood glucose(FBG),homeostasis model insulin resistance index(HOMA-IR)and levels of inflammatory factors[serum interleukin 1(IL-1),interleukin 6(IL-6)and tumor necrosis factor α(TNF-α)]before and after treatment were compared between the two groups.[Results]Compared with before treatment,the scores of SAS and SDS,TCM symptom scores,FINS,FBG and HOMA-IR,serum levels of IL-1,IL-6 and TNF-α were decreased in the electrical stimulation group after treatment(P<0.05).In the control group,the scores of TCM symptoms and FINS,FBG and HOMA-IR were decreased(P<0.05).Compared with the control group,the scores of SAS and SDS,TCM symptom scores,FINS,FBG and HOMA-IR,serum levels of IL-1,IL-6 and TNF-α were decreased in the electrical stimulation group after treatment(P<0.05).[Conclusion]The application of auricular vagus nerve electrical stimulation in the treatment of PCOS patients can effectively improve the anxiety and depression,improve blood glucose metabolism and reduce inflammation.