朗格汉斯细胞组织细胞增多症(Langerhans cell histiocytosis,LCH)是一种以树突状细胞弥漫增殖浸润为主的罕见肿瘤性疾病,可累及全身各个系统,临床症状缺乏特异性.成人LCH的临床表现和治疗策略与儿童LCH有所不同,因此需要针对成人患者采取个体化的治疗方案.近年来除了手术、放化疗之外,靶向治疗以及免疫治疗也在LCH的临床治疗中崭露头角.本文就LCH的靶向治疗和免疫治疗的最新进展作一简要综述.
Langerhans cell histiocytosis(LCH)is a rare disease characterized by proliferation and infiltration of dendritic cells,which can affect various systems throughout the body.The clinical manifestations of adult LCH differ from those in children,thus personalized treatment strategies are required for adult patients.In addition to surgery,radiotherapy and chemotherapy,targeted therapy and immunotherapy have emerged as potential treatment options in recent years.This article provides a brief review of the latest developments in targeted therapy and immunotherapy for LCH.