目的:探究18 F-氟脱氧葡萄糖(FDG)PET/CT代谢参数及异质性指数(HI)与胃癌临床病理特征之间的关系.方法:回顾性分析74 例经病理证实的胃腺癌患者的18 F-FDG PET/CT资料及临床病理资料.测量原发灶最大标准化摄取值(SUVmax)、平均标准摄取值(SUVmean)、肿瘤代谢体积(MTV)、总糖酵解量(TLG)、HI.HI-1 为感兴趣区内SUV值的变异系数(CV),HI-2 为不同SUVmax阈值下MTV值的线性回归斜率的绝对值.运用Spearman秩相关及Logistic回归分析,评估上述参数与胃癌临床病理特征之间的相关性.结果:标准摄值(SUV)及HI在不同分化程度的胃癌中差异具有统计学意义(P<0.01),分化程度与SU-Vmax及HI-1 均呈中度正相关(r值分别为 0.32、0.39,均P<0.05).含有低黏附细胞成分胃癌的SUV及HI-1 均较低(P<0.05).总糖酵解量(TLG)≥57.5 g 为Ⅳ期胃癌的独立危险因素[OR:6.089(1.08,34.33)].结论:18 F-FDG PET/CT代谢参数及HI可反映部分胃癌临床及病理信息.
Objective:To investigate the relationship between18 F-FDG PET/CT metabolic parameters and hetero-geneity index(HI)and the clinicopathological features of gastric cancer.Methods:The 18 F-FDG PET/CT and clinicopathological data of 74 patients with pathologically confirmed gastric adenocarcinoma were retrospectively ana-lyzed.Maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVmean),tumor met-abolic volume(MTV),total glycolysis volume(TLG),and HI were measured in the primary foci.HI-1 was the co-efficient of variation(CV)of SUV values within the region of interest,and HI-2 was the absolute value of linear re-gression slopes of the MTV values at different SUVmax thresholds.Spearman's rank correlation and Logistic regres-sion analysis were used to assess the correlation between the above parameters and clinicopathologic features of gas-tric cancer.Results:SUV value and HI were significantly different in gastric cancers with different degrees of dif-ferentiation(P<0.01),and the degree of differentiation was moderately positively correlated with both SUVmax and HI-1(r =0.32,0.39,all P<0.05).The SUV value and HI-1 were lower in gastric cancers containing low adherent cell components(P<0.05).TLG≥57.5 g was an independent risk factor for stage Ⅳ gastric cancer[OR:6.089(1.08,34.33)].Conclusion:18 F-FDG PET/CT metabolic parameters and HI reflect clinical and pathological information of some gastric cancers.