类风湿关节炎(RA)是一种累及多关节的慢性炎性自身免疫性疾病。 RA 发病机制、治疗策略以及并发症的防治一直是学者们的研究焦点。瘦素(Leptin)是一种主要由白色脂肪组织分泌的脂肪细胞因子,参与多种病理生理过程,包括维持能量平衡、调节免疫和炎症反应以及骨代谢等。 Leptin 被认为是一种炎性细胞因子,参与 RA的发病,并可能成为 RA 疾病活动和关节破坏指标以及潜在治疗靶点。
Rheumatoid arthritis( RA) is a chronic inflammatory autoimmune disease,characterized by systemic, peripheral polyarthritis. RA pathogenesis,treatment strategies and the prevention and treatment of complications have always been the focus of scholars. Leptin is a kind of adipokine secreted mainly by white adipose tissue. It is involved in many pathophysiological processes, including maintaining energy balance, regulating immune and inflammatory responses,bone metabolism and etc. Leptin is thought to be an inflammatory cytokine playing an important role in the pathogenesis of RA,and may be used as an indicator of disease activity and joint destruction as well as a potential ther-apeutic target.