miRNAs与腹膜纤维化关系的研究进展 / Research on the relationship between miRNAs and peritoneal fibrosis
- Resource Type
- Academic Journal
- Authors
- 李栋; 闫铁昆; LI Dong; YAN Tiekun
- Source
- 天津医药. 44(10):1287-1290
- Subject
- 微RNAs
腹膜后纤维化
间质细胞
腹膜透析
综述
上皮间充质转分化
microRNAs
retroperitoneal fibrosis
stromal cells
peritoneal dialysis
review
epithelial mesenchymal transdifferentiation
- Language
- Chinese
- ISSN
- 0253-9896
近年发现微小RNA(miRNAs)是转录后基因调控的关键因素,参与诸多疾病的发生、发展。腹膜透析是终末期肾脏疾病的主要替代治疗方法之一,腹膜纤维化是导致腹透患者退出腹透治疗的最主要因素,制约了腹膜透析的应用和发展。miRNAs与腹膜纤维化发生密切相关。本文就miRNAs在腹膜纤维化发病机制及治疗中的作用进行综述。
In recent years, microRNAs (miRNAs) have been found to be one of the key factors of post transcriptional gene regulation, which are involved in occurrence and development of many diseases. Peritoneal dialysis (PD) has become an effective alternative treatment approaches for patients with end stage renal disease (ESRD). Peritoneal fibrosis is one of the most important factors leading patients to withdraw from long-term PD, hence restricts the application and development of PD. MicroRNAs are closely related to the development of peritoneal fibrosis. This article reviews the role of miRNAs in the pathogenesis and treatment of peritoneal fibrosis.